The first occurrence.
Remember Your servants, Abraham, Isaac, and Jacob; look not to the stubbornness of this people, nor to their wickedness, nor to their sin. Deu 9:27
The primitive root.
resh ר = the head of man, thus head, first, top, beginning, man
shin ש = two front teeth, thus sharp, press, eat, two, again
ayin ע = the eye, thus watch, know, shade
The story: That which was from the beginning (resh), rejected again (shin) with malice aforethought (ayin). Thus, to depart from the ways of God. Adam departed from His ways the first time, perhaps unthinkingly; all the wicked since then depart from His ways the second time, knowing what they are doing.